Elbows knees and punches VS eye, throat, and groin strikes?

So you're asking for advice in regards to when to use clean fighting and dirty fighting? Dirty fighting, in the terms you're putting it in, are moreso for defense whereas clean fighting is where you actually want to fight the other person. I don't promote dirty fighting because I think it's kind of weak to kick someone in the groin to get them on the ground and start pounding away at their face while they're defenseless.